It’s 2019 and only recently have the mysteries within the field of cannabis pharmacopeia started to unfold. Before 1964, the year Dr. Raphael Mechoulan (et all) first isolated the molecules THC and CBD, there was no concrete understanding as to how cannabis worked as an intoxicant or as a medicine. Since his first discovery, it has been Dr. Mechoulan’s lifelong work to uncover the vast complexities within the field of Cannabis Pharmacopia.
Cannabis is an extortionary drug in a number of ways, but one notable fact is that there has never been a case of human-related cannabis overdose. Ever! This is due to the complex relationship between cannabis and the human body. To start, the human body contains a system of neurotransmitters precisely located throughout the body called the Endocannabinoid System. These neurotransmitters are known as endogenous cannabinoids; cannabinoids made by the human body. These neurotransmitters are largely responsible for many metabolic and hormonal functions in our bodies such as sleep, hunger, sex drive, pain management, bone development, and so on. Endogenous cannabinoids have actually been found in woman’s breast milk.
Phytocannabinoids like THC and CBD, on the other hand, are found in the cannabis plant. Phytocannabinoids mimic endogenous Endocannabinoid System. This system is made up of two cannabinoid receptors, the CB1, and CB2 receptors. The two main THC and CBD. These receptors are located in almost every part of the body and brain. The only location cannabinoid receptors are NOT found, are in the respiratory or cardiac centers of the brain stem: The centers of the brain that deal with breathing and heart rate. Therefore, the reason there has never been a cannabis overdose is that the
biomechanics of our bodies just wouldn’t allow it. It is estimated that an adult human would have to inhale roughly 1,500 pounds of cannabis in 15 minutes to achieve an overdose. However, one would assume a person would actually die of asphyxiation being that deprived of oxygen for that long. So either way, it seems like a difficult task to undertake.
Because of this, cannabis is probably the safest drug to administer on your own as an adult use or medicinal use product. The worst side effects inexperienced users could expect to happen after consuming cannabis would be an extremely dry mouth, eating the contents of their fridge, and a possible state of paranoia. So be sure to have candles lit with some calming music to help prevent any negative thoughts for the duration of your cannabis use. Most importantly, enjoy!